“Understanding the Role of Human epidermal growth factor receptor 2 (HER2) in various Cancers and its Therapeutic Implications.’’

Download or read book “Understanding the Role of Human epidermal growth factor receptor 2 (HER2) in various Cancers and its Therapeutic Implications.’’ written by Dr. Hakim Saboowala and published by Dr.Hakim Saboowala. This book was released on 2019-08-06 with total page 48 pages. Available in PDF, EPUB and Kindle. Book excerpt: The human epidermal growth factor receptor (HER) family of receptors plays a central role in the pathogenesis of several human cancers. · It is a member of the epidermal growth factor receptor family having tyrosine kinase activity. Dimerization of the receptor results in the autophosphorylation of tyrosine residues within the cytoplasmic domain of the receptors and initiates a variety of signaling pathways leading to cell proliferation and tumorigenesis. Amplification or overexpression of HER2 occurs in approximately 15–30% of breast cancers and 10–30% of gastric/gastroesophageal cancers and serves as a prognostic and predictive biomarker. HER2 overexpression has also been seen in other cancers like: · Ovary, · Endometrium, · Bladder, · Lung, · Colon, and · Head and Neck. The introduction of HER2 directed therapies has dramatically influenced the outcome of patients with HER2 positive breast and gastric/gastroesophageal cancers; however, the results have been proved disappointing in other HER2 overexpressing cancers. An attempt has been made in this Booklet to discuss the role of HER2 in various cancers and therapeutic modalities available targeting HER2. …….Dr. H. K. Saboowala.M.B.(Bom) M.R.S.H.(London)