OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 498: In vitro Phototoxicity - Reconstructed Human Epidermis Phototoxicity test method

Download or read book OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 498: In vitro Phototoxicity - Reconstructed Human Epidermis Phototoxicity test method written by OECD and published by OECD Publishing. This book was released on 2023-07-04 with total page 28 pages. Available in PDF, EPUB and Kindle. Book excerpt: Skin phototoxicity (photoirritation) is defined as an acute toxic response elicited by topically or systemically administered photoreactive chemicals after the exposure of the skin to environmental light. The in vitro reconstructed human epidermis phototoxicity test (RhE PT) is used to identify the phototoxic potential of a test chemical after topical application in reconstructed human epidermis (RhE) tissues in the presence and absence of simulated sunlight.