Molecular Determinants of Prostate Cancer Progression Across Race-Ethnicity
Author | : |
Publisher | : |
Total Pages | : 19 |
Release | : 2003 |
ISBN-10 | : OCLC:74251610 |
ISBN-13 | : |
Rating | : 4/5 ( Downloads) |
Download or read book Molecular Determinants of Prostate Cancer Progression Across Race-Ethnicity written by and published by . This book was released on 2003 with total page 19 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Prostate Cancer Center Initiation grant has been designed to identify genetic and molecular markers of prostate cancer progression within and between racial ethnic groups (African-Americans, Latinos, Whites, Japanese) at substantially distinct underlying risk of prostate cancer. Our Epidemiology Core has obtained signed tissue releases from prostate cancer patients to date identified during follow-up of the Hawaii/Los Angeles Multiethnic Cohort study and has procured 438 tissue samples to date (163 African-Americans, 163 Latinos, 74 Caucasians, and 38 Japanese). These have been processed histopathologically by Project C, which has completed immunohistochemical staining for COX-2, p27, and Caveolin-1 markers with analysis of additional markers ongoing. Project B, studying the androgen receptor (AR) gene in detail, has conducted functional studies to understand non-steroidal activation of AR signaling. Project A, studying the SRD5A2 gene in detail, has characterized a series of the somatic mutations identified in tumors to date using site directed mutagenesis assays.