Maternal Vitamin D in Early Pregnancy and the Risk for Gestational Diabetes Mellitus

Download or read book Maternal Vitamin D in Early Pregnancy and the Risk for Gestational Diabetes Mellitus written by Bhowmik Bishwajit and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Maternal vitamin D in early pregnancy and the risk for gestational diabetes mellitusB. Bhowmik1, T. Siddiquee1, A. R. Khan1, G.A. Hitman2, A. K. A. Khan1, A. Hussain11Centre of Global Health Research, Diabetic Association of Bangladesh, Dhaka, Bangladesh2Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Blizard Institute: 4 Newark Street, London E1 2AT, UKBackground: Conflicting results currently exists on the association between vitamin D and glucose metabolism. The role of maternal vitamin D status in gestational diabetes mellitus (GDM) is not clear.Aim: To observe the association between maternal vitamin D concentrations in early pregnancy and risk for GDM. Method: A total of 746 women attended in a randomized controlled trial conducted in 5 different areas of capital Dhaka, Bangladesh. Serum 25-hydroxyvitamin D (25-[OH] D) was measured at 8-14 weeks of pregnancy. All participants underwent oral glucose tolerance test at 24-28 weeks of gestation. GDM was defined following the International Association for Diabetes in Pregnancy Study Group (IADPSG) criteria. Logistic regression analysis was performed to assess the independent association between vitamin D and GDM. Results: In this study, 176 (23.6%) women were diagnosed with GDM at 24-28 weeks of pregnancy. Among women who had developed GDM, maternal serum D concentrations at 8-14 weeks of gestation were significantly lower than women without GDM (54.2 vs. 48.1 ng/ml, P = 0.040). Incidence of GDM in women with vitamin D deficiency (