Intermolecular Cross-talk in Tumor Metastasis

Download or read book Intermolecular Cross-talk in Tumor Metastasis written by George G. Skouteris and published by IOS Press. This book was released on 1999 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metastasis of tumours is a sequence of events taking place after the appearance of a primary tumour. The potency of a tumour to metastasise greatly depends on the molecular interactions between tumour components (cellular differentiation and heterogeneity, surface antigenic determinants etc.) and the micro-environment. The complexity and diversity in the composition of tissue micro-environment is in great extent determining the metastatic behaviour or a primary tumour. Extracellular matrix composition, rearrangement of cytoskeleton, cell antigenicity , expression of metastasis-related novel genes, cell adhesion and novel therapeutical approaches such as blockage of angiogenesis, are the major topics discussed in detail in this volume.