Inhibitors of Cyclin-dependent Kinases as Anti-tumor Agents

Download or read book Inhibitors of Cyclin-dependent Kinases as Anti-tumor Agents written by Paul J. Smith and published by CRC Press. This book was released on 2006-10-25 with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of few books to cover all aspects of cyclin-dependent kinases (CDKs), this volume examines CDKs as molecular and functional entities, their role in various disease processes, and their potential for pharmacological modulation. The book first explains the integration of cell cycle control pathways, opportunities for targeting, targets of inhibitors, and the evaluation of CDK inhibitors. Then it examines the design, development, and chemistry of small molecule CDK inhibitors. The final section assesses the current status of CDK inhibitors in clinical trials, the therapeutic deployment challenges of small molecule inhibitors, and the future prospects of CDK inhibitors as anticancer agents.