Nutritional Effects Upon Expression of a Melanotic Tumour Gene in Drosophila Melanogaster

Download or read book Nutritional Effects Upon Expression of a Melanotic Tumour Gene in Drosophila Melanogaster written by and published by . This book was released on 1968 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: A brief review is given of lesions in insects which have been termed "tumours" in the literature, and of previous work on the melanotic tumour gene, tu 83.9« The ultimate goal of work on nutritional modification of gene action, and the limitations of the method in practice, are discussed. This goal is to define the normal function of a primary gene product, whose alteration due to mutation produces a specific, localised abnormality of morphogenesis. Various theoretical expectations are discussed, as to the function of the wild type product of such a gene.The series of events leading to tumour formation, as seen at the level of cell morphology and behaviour, is described.The general nutritional effects of a range of dietary sterols on Drosophila are investigated, and the results disoussed in the context of work, reported in the literature, on the functions of sterols in insects. The effects of the same range of sterols upon expression of tu 83.9, as seen in inbred strains, are then presented and discussed in relation to various hypotheses 'which might explain them.The effects upon tumour expression of dietary treatments thought to influence respiratory metabolism are presented and discussed.Experiments involving the use of specific inhibitors of terpenoid metabolism are discussed, in relation to the findings of Bryant (D.Phil. thesis for University of Sussex, 1967) concerning the effeots upon tumour expression of hormonally active materials.Results are given of attempts to reveal, by means of dietary treatments, effects of the tumour gene upon general development.Certain nutritional features are discussed, of strains of flies which are products of selection for high and low tumour expression from a common base population.The results are linked in a discussion.