As clinicians begin to realize the important role of dose-finding in the drug development process, there is an increasing openness to "novel" methods proposed i

This book presents the continual reassessment method (CRM) as a tool for dose-finding studies. With a focus on the implementation and practice of the CRM and it

This is a comprehensive major reference work for our SpringerReference program covering clinical trials. Although the core of the Work will focus on the design,

Dose-finding experiments define the safe dosage of a drug in development, in terms of the quantity given to a patient. Statistical methods play a crucial role i

This book provides a comprehensive introduction to statistical methods for designing early phase dose-finding clinical trials. It will serve as a textbook or ha