Limiting RNA polymerase II (Pol II) at various stages of the transcription cycle is critical for gene regulation, which often occurs during the elongation stage

The expression of a gene begins by transcribing a target region on the DNA to form a molecule of messenger RNA. As transcription is the first step of gene expre

During RNA synthesis, RNA polymerase (RNAP) can temporally halt nucleotide addition by pausing. Transcriptional pausing plays a central role in regulation of tr

RNA polymerase II (pol II) pausing, elongation and termination are important mechanisms for controlling pol II distribution and transcriptional output during th