In the present update, the state-of-the-art with respect to the validated methods of the 3Rs (Refinement, Reduction and Replacement) strategy of Russell et al.

Since July 2013, Regulation (EC) No 1223/2009 applies for cosmetic products. Their safety-in-use is, as was also the case for Directive 76/768/EEC, established

The "Notes of Guidance for Testing of Cosmetic Ingredients and Their Safety Evaluation by the SCCS" is a document compiled by the members of the Scientific Comm