Bench to Bedside: Translating Pre-clinical Research Into Clinical Trials for Childhood Brain Tumors

Download or read book Bench to Bedside: Translating Pre-clinical Research Into Clinical Trials for Childhood Brain Tumors written by and published by Frontiers Media SA. This book was released on 2023-09-05 with total page 108 pages. Available in PDF, EPUB and Kindle. Book excerpt: umors arising in the brain are the most common solid cancers in children. They are the major cause of childhood cancer deaths. Indeed, more children die from brain tumors than any other disease. Despite improvement in cure rates towards the end of the 20th century, survival statistics have remained unchanged over the past two decades and remain at a level well below that of other childhood cancers, such as leukemia. Also, survivors have a high risk of significant permanent adverse side effects that require a lifetime of clinical management, significantly impacting health systems and quality of life for patients. The lack of advancements in childhood brain tumor treatment was due to deficiencies in knowledge about the underlying biological causes. However, pediatric neuro-oncology has undergone an exciting and dramatic transformation during the past 10 years, driven by advances in genomic technology and international collaboration. Armed with this new knowledge, there is a tremendous opportunity to personalize the treatment by developing novel therapeutic approaches that are tailored to each molecular subtype of these devastating brain cancers to improve the cure rate while minimizing toxicities.